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KMID : 1123920030170061509
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 6 p.1509 ~ p.1513
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Screening of Antifungal Natural Products with Inhibitory Effects on (1,3)β-glucan Synthase
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Chun Hyun-Ja
Kim Young-Sun
Lee Young-Haeng
Kwak Geu-Byum
Kwon Suk-Young
Kwon Tae-Oh
Chai Geu-Yun
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Abstract
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Antifungal activities of the extracts from 26 medicinal plants were investigated utilizing paper-disk diffusion method and (1,3)β-glucan synthase inhibitory assay. (1,3)β-glucan synthase is considered as valuable target in the development of antifungal agents. Among the screened extracts, the ethyl acetate extract of Equisetum arvense, the ethyl acetate extract of Polygonum aviculare, the butanol extract of Crataegus pinnatifida and the n-hexane extract of Saussurea lappa showed significant antifungal activities on Candida albacans in both disk diffusion and enzyme assays.
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KEYWORD
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(1 , 3)β-glucan synthase, Candida albacans, Antifungal activity
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